Dr. KWOH Chee Keong


Title: Fundamental of Genomic Sequence Analysis

Topic Area: Bioinformatics Sequence Analysis

 

  • PhD, DIC, MSc(ISE), BEng(EE), PGDIG,
  • Sr.MIES, M.ICAAS, M.AMBIS
  • Associate Professor,
  • Division of Information Systems, School of Computer Engineering
  • Programme Director, MSc (Bioinformatics)
  • Nanyang Technological University
  • Blk N4 #2A-32, School of Computer Engineering,
  • Nanyang Avenue, Singapore 639798
  • Tel: (65) 6790 6057 Fax: (65) 6792 6559
  • Home page URL: http://www.ntu.edu.sg/home/asckkwoh/�
  • Teaching experience: 15 year

Abstract:

The revolution in molecular biology and computer science has enabled high throughput analysis of tons of the genomic sequences generated from sequencing projects.

This tutorial introduces genomic sequence analysis at the introductory level.

  • Basic concepts of molecular genetics and computational biology, access to genomic sequence data and literature in bioinformatics, and access to genomic sequence data using GenBank, Ensembl, etc.
  • Pairwise sequence alignment for DNA and protein sequence alignment, and search. The commonly using scorin matrices. The Basic Local Alignment Search Tool (BLAST) algorithms, BLAST search strategies and practices in genomic database search.
  • Multiple sequence alignment for comparison of three or more biological sequences, generally protein, DNA, or RNA. In many cases, to infer evolutionary relationship where sharing a lineage (descended from a common ancestor).


Requirements: An introductory knowledge of mathematics and statistics

Tutorial Outline:

  • The course materials are developed around the textbook Bioinformatics and Functional Genomics (2nd Edition) by Jonathan Pevsner, John Wiley & Sons, Inc., 2009.
  • Total time available for the tutorial: 4 hours including a 30 min break.